The Sanjana Lab at NY Genome and NYU works at the interface of bioengineering, neuroscience and cancer. Our lab employs a multi-disciplinary approach, combining genome engineering, pooled genetic screens, molecular genomics, electrophysiology, and imaging, to dissect the inner workings of the human genome and to attack diseases like autism and cancer.
As molecular engineers, we are inspired by the natural world and use molecular cloning to harness these tools to tackle hard problems in biology. Recently, we have developed technologies for high-throughput genome editing and functional genomic screens, including genome-wide loss-of-function screens in vitro and in vivo and scanning mutagenesis to identify functional elements in the noncoding genome.