The Sanjana Lab at NY Genome and NYU works at the interface of bioengineering, neuroscience and cancer. Our lab employs a multi-disciplinary approach, combining genome engineering, pooled genetic screens, molecular genomics, synthetic biology, and imaging, to dissect the inner workings of the human genome and to develop next-generation therapies for diverse diseases, including cancer, rare inherited disorders, brain disorders, autoimmunity and others.
As molecular engineers, we are inspired by the natural world and use molecular cloning to harness these tools to tackle hard problems in biology. Over the past decade, we have developed technologies for high-throughput genome editing and functional genomic screens, including genome-wide screens in vitro and in vivo and a suite of methods — including scanning mutagenesis and precise variant insertion — to identify functional elements in the noncoding genome.